For mass production in livestock, antibiotics are growth promotants that cannot be ignored that serve as major tool for production farm efficiency. Antibiotic supplementation in the diet improves growth and feed performance. The market has changed for a decade now, new trends in lifestyles in developed countries shaped consumer demands nowadays. As a market driven industry, the usage of antibiotics in feeds is under full scrutiny in a changing niche market for dietary composition including the usage of alternative feed additives that would meet the requirements of the industry with optimum management of corporate social responsibility.
The major challenge for technical persons in adapting antibiotic is the development of resistance from animal consumption that are being transferred to humans. The phenomenon of transferable resistance although controversial, deserves attention by the scientific community . The prohibition increased the incidence of subclinical diseases, and as a result the use of therapeutical doses of antibiotics in treating sick animals augmented considerable. The feedmilling and livestock industry adapted to the new situation by improving environmental control of poultry, livestock and aquaculture facilities through an elevated management of animal health and animal nutrition as well.
There is an increasing demand to find alternatives to the use of feed grade antibiotics to promote growth and prevent disease in food producing animals. And one of the most promising feed additive ingredient to be used under Green technology for antibiotic replacement are BETA GLUCANS. Using immunomodulators for animals, it improves performance, health status which are being referred to as Biological Response Modifiers - because of their ability to potentiate the immune system. BETA GLUCANS with B 1-3, and B 1-6 glycosidic linkages are major structural components of yeast and fungal cell walls. BETA GLUCANS are naturally occurring polysaccharides. These glucose polymers are produced by a variety of plants, such as oat, barley and seaweed. BETA GLULCANS are the constituents of the cell wall of pathogenic bacteria like Pneumocystis carinii, Cryptococcus neoformans, Aspergillus fumigatus, Histoplasma capsulatum, Candida albicans) and fungi (Saccharomyces cerevisiae).
It has been a common knowledge in the scientific community that BETA GLUCAN is the most known powerful immune stimulant and very powerful antagonist to both benign and malignant tumors; it lowers cholesterol and triglyceride level, normalizes blood sugar level and heals, rejuvenates the skin with other immune enhancer benefits. IMMUNOWALL: BETA GLUCAN is a yeast based Saccharomyces cerevisae with an inner layer of insoluble BETA GLUCAN (30%-35%) middle layer – of soluble BETA GLUCAN(20–22%), external layer – of glycoprotein(30%) . The stimulatory effects of IMMUNOWALL on specific and nonspecific immune responses have been demonstrated in mammals. IMMUNOWALL are polysaccharides of D-glucose monomers linked by by β-glycosidic bonds. These are diverse group of molecules that can vary with respect to molecular mass, solubility, viscosity and three dimensional configuration. IMMUNOWALL is a “ biological response modifier” since it activates the immune system. IMMUNOWALL provides improvements for fewer infections, reduced mortality and stronger tensile strength of scar tissue. IMMUNOWALL : BETA GLUCANS isolated from yeast are recognized as GRAS (Generally Regarded as Safe) under “yeast extract” and the FDA accepted notification of the GRAS affirmation.
IMMUNOWALL immunomudulation of macrophage provides the result of activation of macrophages with the interaction of BETA GLUCAN in the product since its source is coming from Spray dried molasses. IMMUNOWALL spray dried molasses yeast has b(1,6) branches that are further elaborated with additional b(1,3) regions. These structural differences can have large implications for the activity of the b-glucan. In general, in vitro studies have suggested that large molecular weight or particular b-glucans can directly activate leukocytes, stimulating their phagocytic, cytotoxic, and antimicrobial activities, including the production of reactive oxygen and nitrogen intermediates.
IMMUNOWALL in swine, poultry, and aquaculture is one way of decreasing disease susceptibility and presumably increasing performance in growth. IMMUNOWALL stimulates both specific and non specific immune responses. In swine diets, the mechanism responsible for the positive results obtained from feeding BETA GLUCAN to weaned pigs could be evoked by eliciting specific immune reactions. This growth enhancement is a result of an increase in nonspecific immunity and at the same time tolerance to oral antigens can be increased too, including immunomodulator in the creep feed stage can abate soybean induced hypersensitivity of the piglets. IMMUNOWALL decrease inflammatory cytokine responses which allows the nutrients to be partitioned toward growth.
IMMUNOWALL is a prebiotic composed of polysaccharide of immune stimulating action, derived from the Sacharomyces cerevisae yeast cell wall. Polyssacharides (80-90 % of the cell wall) of IMMUNOWALL are constituted of glucans, mannans (mannose polymers), chitins (glucosamine polymers), and galactans (galactose polymer). Other compounds, such as fucose, rhamnose, xylose and uronic acids are also present in smaller amounts. BETA GLUCANS refer to a large group of d-glucose polymers with glycosidic bridges and 1,3 and 1,6 bonds. IMMUNOWALL also has proteins, lipids and phosphate in its composition.
What makes IMMUNOWALL highly differentiated among other brands? The efficacy of a good glucomannan complex is directly associated to nutrient composition, especially carbohydrate composition. For a prebiotic based on yeast cell wall to be really efficient, it must have adequate concentrations of 1,3 and 1,6 glucans (50-60%) and mannan oligossacharides (MOS) 40% to adequately perform its immune stimulating action.
Specific Target Areas Being Resolved by IMMUNOWALL: Since it is 100% natural prebiotic without residues, it prevents colonization of the intestinal tract by pathogens, stimulates the immune activity of the phagocytic cells (macrophages, neutrophils, lysozyme, and interferon). IMMUNOWALL increases 25% secretion of IgA, antigens of the intestinal tract that prevent the adherence of pathogenic bacteria to the cells of the intestinal epithelium. It enhances the action of beneficial bacteria such as Lactobacillus and Bifidobacteria and at the same time act as an adbsorbent too.
As a whole, IMMUNOWALL eliminates the costs of medication coming from scouring complex challenge in the farm. In this alone, costs from morbidity and mortality can be best equated through an improved animal health performance. Since, IMMUNOWALL is systemic and not acting on gut alone, certainly, production parameters of feed conversion ratio can be best reflected in a very strong competitive farm efficiency values. IMMUNOWALL is hitting two birds in one stone: costs and market driven ; an alternative material in providing SAFE FEED FOR SAFE FOOD!
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